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Frances Arnold: New enzymes by evolution

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  • Anon
    Anon 2 ай бұрын

    What’s so unreal about her is that she probably would have revolutionised solar power if she stayed in that area. Brilliant. Destined to make a big difference

  • Peijun Li
    Peijun Li 2 жыл бұрын +1

    oh wow, what a inspiring and amazing talk about biocatalysis.

  • Nixon Lee
    Nixon Lee 4 жыл бұрын +5

    It's a new world to run in the speed of light! Thanks for Dr.Frances Armold's efforts!

  • Ronald Abraham
    Ronald Abraham 4 жыл бұрын +9

    Congratulations for the historical achievement 😍😍😍

  • ARGHYA BANERJEE
    ARGHYA BANERJEE 3 жыл бұрын +3

    Thank you mam for your valuable lectures, regards from India 💐

  • Venu Gopal
    Venu Gopal 2 жыл бұрын

    let us give a big salute to our beloved Darwin too for paving the way for wonderful scientists like Francis Arnold....it is high time a global investment is ensured to take up such great researches in evolutionary biology esp in the light of thee Covid19 outbreak...virology should have a strict evolutionary orientation...

  • PAY ATTENTION
    PAY ATTENTION 4 жыл бұрын +6

    The way you implement the Noble ideas into society is the prize
    - How it benefits mankind.

  • Sebastian Aguiar Brunemeier
    Sebastian Aguiar Brunemeier 4 жыл бұрын

    Awesome talk

  • SHRUTI HALLI
    SHRUTI HALLI 3 жыл бұрын +1

    Congratulations, I am diehard lover of GENETICS

  • Physics is the life: Arun Pujer
    Physics is the life: Arun Pujer 4 жыл бұрын +3

    congratulations , unbelievable, and it is the only near ever possible hopes in the future

  • Jason Wiley
    Jason Wiley Ай бұрын

    Is t here currently any research on creating designer proteins/ enzymes. By which I mean using AI AND SUPERCOMPUTERS to create enzymes that don't exist in nature. These could be used for example break down PFAs.

    • Jason Wiley
      Jason Wiley Ай бұрын

      I asked this question before I watched this video. She talked about designer enzymes

  • Mukund Paidhungat
    Mukund Paidhungat 5 жыл бұрын +2

    Brilliant. Try again, fail again, fail better harnessed as a portal into a whole new chemistry of life, I suspect frances Arnold will be back in Stokholm ere to long.

  • Dibakar Hajong
    Dibakar Hajong 4 жыл бұрын +1

    Congratulations Frances Arnold

  • Pedro Zaragoza
    Pedro Zaragoza 4 жыл бұрын +1

    Brilliant research that shows intelligent design.

    • rumraket38
      rumraket38 4 жыл бұрын +1

      What a fatuous remark for a lecture demonstrating work that would not be possible if biological evolution of new protein functions was not a reality.

  • Esquina del Cronopio
    Esquina del Cronopio 2 жыл бұрын +2

    👏👏👏

  • Anon2150
    Anon2150 3 жыл бұрын +4

    4:00
    "Biology is great, but it can't do what I can do."(?)
    Let's not forget, biology and chemistry created you, silly.
    I'm just saying, it's the more impressive thing.

    • TearringNable
      TearringNable 3 жыл бұрын +3

      She was quoting chemists versus her stance on bio-chemistry relations, so hard chemistry versus bioconversion

  • Richard Shane
    Richard Shane 4 жыл бұрын +1

    I compliment your work however as an engineer why are you not looking at the Crux of the problem you're part of the cog of the problem I understand you have a career a life a reality but you do realize you can change that reality in a instant, right?
    So which reality have you discovered?
    there's so many out there...
    for all of you, the natural world doesn't really need anybody's help
    however continue on as part of the cog of the problem and not the solution but we all understand you're driven by your academic nature to fix things remember to fix something you need to know what the actual problem really is, not a Band-Aid, especially in biochemistry

    • SCIENCE & ENGINEER
      SCIENCE & ENGINEER 9 ай бұрын +1

      You sound like a messy, troubled engineer. Maybe reorganize ur thoughts first before making more messes instead of work?

    • cesare the somnambulist
      cesare the somnambulist 4 жыл бұрын +1

      @Lenny Carlson XDDDDD

  • Jitnarayan Shah
    Jitnarayan Shah 3 жыл бұрын

    Congratulation wonderful invention

  • Ken Jackson
    Ken Jackson 2 жыл бұрын

    Fascinating! I don't mean to take _anything_ away from this excellent work, but I'm amazed that such brilliant people have so much naive faith in evolution. At 4:28 it's acknowledged that enzymes are *so well designed.*
    11:09 _"Imagine just a single protein a few hundred amino acids long, you've got twenty amino acids to work with. That's a really big space of possible sequences. ... It's a really _*_big_*_ number. And, it's mostly empty. ... So how do you search a space of enzymes that's bigger than you can even begin to comprehend and mostly empty?"_
    Good question, but an even better question would be, how did _"nature"_ find the original enzymes? Oh sure, we know a mutation or two can wobble around an _existing_ enzyme and change its function slightly, as you've said and demonstrated. But that _"really big"_ space of 20^450 (or 10^585) permutations is, as you said, well beyond astronomically large. A few billion years just won't cut it.
    A little math, with assumptions very favorable to evolution, will easily show that _"nature"_ couldn't have found _any_ of those enzymes in a trillion trillion trillion trillion years. Seriously. Make some assumptions and do some math.

    • Anon
      Anon 2 ай бұрын

      @Ken Jackson and sorry I’m not trying to come off as dismissive or condescending, as if I knew for a fact your argument was meritless. In fact, I think it’s a good point and you’re making it intelligently, and we should honestly give these numbers a good think (not just dismiss this argument out of hand like some do)-in the worst case, it’ll give us new ideas and some boundaries on our scientific ideas

    • Anon
      Anon 2 ай бұрын

      @Ken Jackson the number gets close when you account for total number of proteins etc, then we’re in the range of 1e50 to 55. I had a feeling youd say that regarding me saying “close” but I should have been more careful. I meant close to what I think is a reasonable estimate, and close when you extended that number from total bacteria ever living to total proteins produced (1e55), not to mention that’s just one branch on the tree of life.
      The difference between proteins and peptides is arbitrary, but usually 50 or greater AA with higher order structure (tertiary structure) makes a protein.
      However the first “proteins” were probably polypeptides, ie just a handful of residues large enough to be useful. There are many extremely useful small polypeptides (not just signalling). Enzymes today are beautiful works of art, exquisitely coordinated, but they don’t need to start that way. As long as there is even slight advantage, that’s enough. Again there’s many current examples of useful polypeptides (

    • Ken Jackson
      Ken Jackson 2 ай бұрын

      @Anon: _"but yes some do start expressing things like efflux proteins to pump out chemotherapeutics"_
      Are they NEW designs of _"efflux proteins"?_ Or are they just unexpectedly expressing an existing design?
      *Anon:* _"I think you're accidentally agreeing with me though--the resistance isn't necessarily good, it just helps it survive."_
      OK, yes, that sounds reasonable.
      In Michael Behe's excellent book, Darwin Devolves, he explains that in his very extensive review professional literature, he found that essentially all mutations that are positively selected did damage.
      (I conclude that no new proteins, molecular machines, gene regulatory networks, chemical pathways, organs or integrated hierarchical bodily systems have ever been documented to have evolved.)
      He starts with he polar bear which has genetic damage that prevents coloring its fur and other genetic damage that allows it to live on a diet of mostly seal blubber. Those damaging changes make it more suited for its environment, so they were positively selected.
      But notice that such damage uses up genetic flexibility. It's unlikely the polar bear will be able to evolve in the other direction.

    • Ken Jackson
      Ken Jackson 2 ай бұрын

      @Anon: _"Another interesting example is inner ear bone evolution."_
      But is that a "Just So" story? Or is there a genetic trail to follow? If you just look at morphologically similar animals or fossils, you can't tell but what you're looking at several totally different designs (perhaps some with degenerative genetic damage) that have just been arranged in an order that supports the wishes of the storyteller.
      *Anon:* _"That redundancy is freed from selection pressure and mutations there will not just outright kill the protein."_
      Yes, I always start with the assumption that there was a gene duplication mutation, which is known to occur sometimes, and one copy of it freely mutates.
      But even when I add the outrageously ludicrous assumption that every organism is born (or hatched etc) with enough mutations to form a unique sequence in that duplicate gene across all time across all organisms in that population, the numbers just don't work.
      Also, most proteins don't work by themselves. They're carefully shaped to work together with others. So even if any one of them evolved into existence, it would give zero benefit without the remaining component proteins. It wouldn't be conserved.

    • Ken Jackson
      Ken Jackson 2 ай бұрын

      @Anon: _"To be clear, do you not believe in natural selection whatsoever ..."_
      Natural selection is observed to have an effect.
      But natural selection can only either kill an organism before it reproduces or let it reproduce. That's the ONLY influence natural selection has.
      Notice that it cannot pick and choose between which mutations an organism has. It's been measured that humans are born with about 100 new mutations per birth and some other animals have been measured with similar rates.
      So if there's a "good mutation" (whatever that means) among those 100, natural selection *can't* select it without also selecting however many damaging mutations might also be among the 100.
      Stated another way, natural selection can only select phenotypically, _not_ genetically.
      *Anon:* _"I will say that I'm a graduating PhD from a good university who has worked in protein chemistry pretty extensively, ..."_
      Congratulations. Yes, you've clearly demonstrated knowledge. I'm sure you have a lot more knowledge than me. But you've not made a convincing argument that any new protein has ever evolved (ignoring 1- or 2-mutation variants of existing already-designed proteins).

  • Frank Fuerbeth
    Frank Fuerbeth 3 жыл бұрын +1

    Exciting!

  • Teresa Johnson
    Teresa Johnson 6 ай бұрын

    🤗👍👏👏👏👏👏👏👏👏👏👏👏👏👏

  • YoutubSUCKZ
    YoutubSUCKZ 2 жыл бұрын

    amazing woman

  • Linga Banoth
    Linga Banoth 4 жыл бұрын +2

    Congratulation Madam

  • Julio de Menezes Pinto
    Julio de Menezes Pinto 4 жыл бұрын

    Congratulations

  • Bernd Stange-Grüneberg
    Bernd Stange-Grüneberg 4 жыл бұрын +1

    kzclip.org/video/05r-FLGtsEQ/бейне.html: "[The protein space] is bigger the United States national debt." Great sense of humour. Congratulations !

  • random miser
    random miser  Жыл бұрын

    intresting

  • Logics Conscience
    Logics Conscience  Жыл бұрын

    Wow

  • random miser
    random miser  Жыл бұрын

    playing with chemistry and calling it evolution..its reaction.

  • 程睿滢
    程睿滢 4 жыл бұрын +1

    may i reupload this video to a nonprofit site bilibili? I'll attach the link below

    • Robit Mr
      Robit Mr 4 жыл бұрын

      不好意思,我看错了,他不让你公开,唉,没办法,版权意识很强

    • Robit Mr
      Robit Mr 4 жыл бұрын

      @程睿滢 哈哈,恭喜up主喜提精彩视频。

    • 程睿滢
      程睿滢 4 жыл бұрын +4

      I'm in China,it's sort of illegal for us to use KZclip, and most people don't have the access. it's such a insightful and inspiring video, it would be nice if more people can see it.
      thinks!

    • MoleCluesTV
      MoleCluesTV  4 жыл бұрын +1

      Hi, is it not possible for you to embed this KZclip video, or simply put the link to it on your site? Best wishes

  • Singh's logical science
    Singh's logical science 3 жыл бұрын +10

    Madam i want to be your student.

  • Stefano Leidi
    Stefano Leidi 3 жыл бұрын

    29:51 she just @vsauce 'd us

  • PAY ATTENTION
    PAY ATTENTION 4 жыл бұрын +2

    Wake up

    • PAY ATTENTION
      PAY ATTENTION 4 жыл бұрын

      Sir or Madam The word Fuck is not called for in this situation - I am sorry I upset you I will watch my mouth if you watch yours.

    • unfriendly bus
      unfriendly bus 4 жыл бұрын

      Fuck i did not even know i was sleeping

    • Fu*k Poe's Law!
      Fu*k Poe's Law! 4 жыл бұрын

      Pay Attention Evolutionism!